What it means
それにしても means “even so” or “nevertheless.” It introduces a speaker’s reaction, judgment, or comment that remains valid despite the situation just mentioned. It often signals surprise, admiration, criticism, or emphasis, and it is commonly placed at the beginning of a sentence followed by a comma. Because it is a fixed connective expression, it does not change form for politeness.
Usage note
それにしても is often used to comment on a previous situation rather than to present a simple logical contrast. Do not confuse it with それでも, which more directly means “even then” or “despite that” and can connect two opposing events or choices.
Example sentences
長時間の会議で疲れた。それにしても、部長の記憶力には驚かされた。
I was tired from the long meeting. Even so, I was amazed by the department manager's memory.
新しい図書館は駅からかなり離れている。それにしても、毎週末たくさんの人が訪れるのは驚きだ。
The new library is quite far from the station. Even so, it is surprising that many people visit every weekend.